inositol polyphosphate 5-phosphatase K; skeletal muscle & kidney-enriched inositol phosphatase (INPP5K, PPS, SKIP)

Function: - inositol 5-phosphatase which acts on a) inositol 1,4,5-trisphosphate b) inositol 1,3,4,5-tetrakisphosphate, c) phosphatidylinositol 4,5-bisphosphate d) phosphatidylinositol 3,4,5-triphosphate - affinity for phosphatidylinositol 4,5-bisphosphate 6-fold higher than for inositol 1,4,5-trisphosphate - may negatively regulate assembly of actin cytoskeleton Structure: - belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family Compartment: - endoplasmic reticulum - following stimulation with EGF, translocates to membrane ruffles Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - highest levels in skeletal muscle, heart & kidney

General

membrane protein phosphomonoesterase

Properties

SIZE: entity length = 448 aa MW = 51 kD COMPARTMENT: endoplasmic reticulum MOTIF: active site SITE: 16-318 ruffle domain {321-448}

Database Correlations

OMIM 607875 UniProt Q9BT40 Pfam PF03372 ENZYME 3.1.3.56

References

UniProt :accession Q9BT40