Search
SKAP complex; astrin-kinastrin complex; SPAG5-kinastrin complex
Function:
- promotes stable microtubule-kinetochore attachments
Structure:
- subunits include: KNSTRN, SPAG5, PLK1, DYNLL1 & SGOL2
Compartment:
- located at the kinetochore-microtubule interface
- localizes to the microtubule plus ends
General
molecular complex
Properties
SUBUNITS: small kinetochore-associated protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S128}
SPAG5 interaction {159-316}
MOTIF: coiled coil {166-216}
coiled coil {248-316}
sperm-associated antigen 5
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S12}
Ser phosphorylation site {S14}
Ser phosphorylation site {S62}
Ser phosphorylation site {S66}
Thr phosphorylation site {T111}
Ser phosphorylation site {S135}
Ser phosphorylation site {S249}
Ser phosphorylation site {S334}
Ser phosphorylation site {S341}
Ser phosphorylation site {S353}
Ser phosphorylation site {S362}
Ser phosphorylation site {S364}
Thr phosphorylation site {T377}
Thr phosphorylation site {T389}
Ser phosphorylation site {S401}
coiled coil {545-608}
glutamine-rich region {617-789}
MOTIF: glutamine residue (SEVERAL)
coiled coil {759-868}
Thr phosphorylation site {T937}
coiled coil {979-1174}
serine/threonine protein kinase PLK1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Thr phosphorylation site {T6}
kinase domain
SITE: 53-305
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 59-67
ATP-binding site
NAME: ATP-binding site
SITE: 82-82
Ser phosphorylation site {S103}
ATP-binding site
NAME: ATP-binding site
SITE: 131-131
Ser phosphorylation site {S137}
aspartate residue {D176}
ATP-binding site
NAME: ATP-binding site
SITE: 178-181
Activation loop {194-221}
ATP-binding site
NAME: ATP-binding site
SITE: 194-194
Thr phosphorylation site {T210}
Thr phosphorylation site {T214}
Ser phosphorylation site {S269}
Ser phosphorylation site {S335}
ubiquitination site (destruction box, D-box)
SITE: 337-340
FOR-BINDING-OF: ubiquitin
Ser phosphorylation site {S375}
POLO box domain {417-480}
MOTIF: Ser phosphorylation site {S450}
Ser phosphorylation site {S461}
Thr phosphorylation site {T464}
Linker {493-507}
MOTIF: Thr phosphorylation site {T498}
POLO box domain {515-584}
MOTIF: domain {538-540}
STATE: active state
dynein light chain 1
COMPARTMENT: cytoplasm
INHIBITS: NO synthase-1
Shugoshin-like 2
COMPARTMENT: cell nucleus
MOTIF: coiled coil {69-116}
Ser phosphorylation site {S266}
coiled coil {452-476}
Ser phosphorylation site {S507}
coiled coil {603-626}
Thr phosphorylation site {T845}
References
UniProt :accession Q9Y448
Components
dynein light chain 1, cytoplasmic (protein inhibitor of neuronal nitric oxide synthase, PIN, DLC1, DYNLL1, DNCL1, DNCLC1, HDLC1)
serine/threonine protein kinase PLK1; polo-like kinase 1; PLK-1; serine/threonine protein kinase 13; STPK13 (PLK1 PLK)
Shugoshin-like 2 (Tripin) (SGOL2)
small kinetochore-associated protein; SKAP; kinetochore-localized astrin-binding protein; kinastrin; kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1 (KNSTRN, C15orf23, SKAP, TRAF4AF1, HSD11)
sperm-associated antigen 5 (astrin, mitotic spindle-associated protein p126, MAP126, Deepest, SPAG5)