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sirtuin 7 (NAD-dependent deacetylase sirtuin 7, silent mating type information regulation 2 homolog 7, SIRT7)
Function:
- probable NAD-dependent deacetylase
NAD+ + an acetylprotein
nicotinamide + O-acetyl-ADP-ribose + a protein
Cofactor: binds 1 Zn+2 per subunit
Structure:
- belongs to the sirtuin family
- contains 1 deacetylase sirtuin-type domain
Compartment: cytoplasm, located under nuclear membrane
Alternative splicing: named isoforms=2
Pathology:
- overexpressed in human thyroid carcinoma cell lines & tissues, but not in adenomas
General
sirtuin (silent mating type information regulation 2 homolog)
Properties
SIZE: MW = 45 kD
entity length = 400 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: arginine-rich region {8-74}
MOTIF: arginine residue (SEVERAL)
DEACETYLASE SIRTUIN-TYPE {90-331}
MOTIF: histidine residue {H187}
Zn+2-binding site
SITE: 195-195
Zn+2-binding site
SITE: 198-198
Zn+2-binding site
SITE: 225-225
Zn+2-binding site
SITE: 228-228
Database Correlations
OMIM 606212
UniProt Q9NRC8
Pfam PF02146
Entrez Gene 51547
References
UniProt :accession Q9NRC8