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sirtuin 3 (NAD-dependent deacetylase sirtuin, silent mating type information regulation 2 homolog 3 mitochondrial, SIRT3)
Function:
1) NAD-dependent deacetylase
2) despite some ability to deacetylate histones in vitro, unlikely to do so in vivo
3) may activate thermogenesis in brown adipocytes [2]
4) linked to circadian rhythms [3]
- may activate mitochondrial metabolism during fasting
NAD+ + an acetylprotein
nicotinamide + O-acetyl-ADP-ribose + a protein
Cofactor: binds 1 Zn+2 per subunit
Structure:
- processed by mitochondrial processing peptidase (MPP) to give a 28 kD product, processing likey essential for enzymatic activity
- belongs to the sirtuin family
- contains 1 deacetylase sirtuin-type domain
Compartment: mitochondrial matrix
Expression: widely expressed
General
mitochondrial protein
sirtuin (silent mating type information regulation 2 homolog)
Properties
SIZE: MW = 44 kD
entity length = 399 aa
COMPARTMENT: mitochondrial matrix
MOTIF: histidine residue {H248}
Zn+2-binding site
SITE: 256-256
Zn+2-binding site
SITE: 259-259
Zn+2-binding site
SITE: 280-280
Zn+2-binding site
SITE: 283-283
Database Correlations
OMIM 604481
UniProt Q9NTG7
Pfam PF02146
Entrez Gene 23410
References
- UniProt :accession Q9NTG7
- Shi T, Wang F, Stieren E, Tong Q.
SIRT3, a mitochondrial sirtuin deacetylase, regulates
mitochondrial function and thermogenesis in brown adipocytes.
J Biol Chem. 2005 Apr 8;280(14):13560-7. Epub 2005 Jan 14.
PMID: 15653680
- Peek CB, Affinati AH, Ramsey KM et al
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative
Metabolism in Mice.
Science. 2013 Sep 19. [Epub ahead of print]
PMID: 24051248