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systemic inflammatory response syndrome (SIRS)
Systemic inflammatory response to a variety of severe clinical insults in the absence of infection. Clinically SIRS resembles sepsis (without documented infection).
Clinical criteria: (same as for sepsis minus documented infection)
1) temp > 38 C or < 36 C
2) heart rate > 90/min
3) respiratory rate > 20/min or paCO2 < 32 mm Hg
4) WBC > 12,000 cells/mm3 or < 4000 cells/mm3 or > 10% bands
Etiology:
1) pancreatitis
2) trauma
3) envenomation
4) disseminated intravascular coagulation (DIC)
5) tumor necrosis syndrome
6) myonecrosis
7) burns
Clinical manifestations: see sepsis
Laboratory: see sepsis
Radiology: see sepsis
Management: see sepsis
Comparative biology:
- topoisomerase-1 inhibitor protected mice from death in experimental models of lethal inflammation [2]
Specific
sepsis
General
syndrome
inflammation
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 17.
American College of Physicians, Philadelphia 1998, 2015
- Rialdi A et al.
Topoisomerase 1 inhibition suppresses inflammatory genes and
protects from death by inflammation.
Science 2016 May 27; 352:aad7993
PMID: 27127234