sin3 repressor complex

Function: - interacts with MeCP2 to repress gene transcription at sites of methylated CpG islands Structure: - subunits: HDAC core complex, SIN3, SAP18, SAP30, SUDS3 Notes: unclear if this is the same as sin3A corepressor complex

Related

Sin3 complex (GO:0016580) Sin3A corepressor complex

General

molecular complex transcriptional silencer (transcriptional repressor)

Properties

COMPARTMENT: cell nucleus SUBUNITS: sin3-protein SAP18 protein SAP30 protein Sin3 histone deacetylase corepressor complex component SDS3 MOTIF: coiled coil {66-171} Sin3 interaction {188-226} histone deacetylase core complex

References

Genes VII, Lewis B., Oxford University Press, NY, 2000

Components

histone deacetylase (HDAC) core complex Sin3 histone deacetylase corepressor complex component SDS3 (suppressor of defective silencing 3 protein homolog, SUDS3, SDS3, SAP45) sin3-associated peptide, 18kD (histone deacetylase complex subunit SAP18, SAP18) sin3-associated peptide, 30kD (SAP30, histone deacetylase complex subunit SAP30, sin3 corepressor complex subunit SAP30) sin3-protein