Contents

Search

silver sulfadiazine (Silvadene)

Tradename: Silvadene. Indications: - prevention & treatment of skin infections in 2nd degree burns & 3rd degree burns - wound dressing for cutaneous ulcers [4] - pressure ulcers - venous stasis ulcers [6] - malodorous wounds - wounds with exudates - suspected high bacterial load - periwound inflammation - slow healing wounds * only use silver dressing if bacteria identified [4] Contraindications: - children < 2 months of age (sulfa drugs compete with bilirubin for protein-binding sites) Caution: 1) G6PD deficiency 2) renal impairment pregnancy-category :value B) safety-in-lactation :value - Dosage: 1) burns: 1% cream applied to thickness of 1/16 inch QD/BID 2) local anesthetic may be needed prior to application Cream (topical): 10 mg/g (1%) 20, 50, 85, 400, 1000 g. Also contains methylparaben & propylene glycol. Pharmacokinetics: 1) up to 1% of silver is absorbed 2) up to 10% of the sulfa component may be absorbed Adverse effects: 1) common (> 10%) - burning 2) less common (1-10%) - itching, rash, erythema multiforme, skin discoloration, hemolytic anemia, leukopenia, agranulocytosis, aplastic anemia, hepatitis, pain, interstitial nephritis, allergic reactions* 3) uncommon (< 1%) - photosensitivity * allergic reactions may be related to sulfa component Drug interactions: - silver may inactivate topical proteolytic enzymes

Related

silver alginate

General

silver dressing

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010 - Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  5. Deprecated Reference
  6. Miller AC, Rashid RM, Falzon L, Elamin EM, Zehtabchi S. Silver sulfadiazine for the treatment of partial-thickness burns and venous stasis ulcers. J Am Acad Dermatol. 2012 May;66(5):e159-65 PMID: 20724028

Component-of

enrofloxacin/silver sulfadiazine enrofloxacin/silver sulfadiazine/sulfadiazine