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sialic acid-binding Ig-like lectin 14 (siglec-14, SIGLEC14)
Function:
- putative adhesion molecule
- sialic acid-binding paired
- receptor which may activate associated receptors
- interacts with TYROBP
Structure:
- belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- mainly expressed in hematopoietic tissues including bone marrow, spleen & fetal liver
- also detected in lung & testis
General
adhesion protein
glycoprotein
immunoglobulin superfamily protein
membrane protein
Properties
SIZE: entity length = 396 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-16}
immunoglobulin superfamily domain {19-136}
immunoglobulin superfamily domain {146-229}
MOTIF: cysteine residue {C164}
MODIFICATION: cysteine residue {C213}
cysteine residue {C213}
MODIFICATION: cysteine residue {C164}
N-glycosylation site {N231}
immunoglobulin superfamily domain {236-331}
MOTIF: cysteine residue {C274}
MODIFICATION: cysteine residue {C319}
cysteine residue {C319}
MODIFICATION: cysteine residue {C274}
transmembrane domain {359-381}
Database Correlations
UniProt Q08ET2
PFAM correlations
References
UniProt :accession Q08ET2