E3 ubiquitin-protein ligase SIAH2; seven in absentia homolog 2; siah-2; hsiah2 (SIAH2)

Function: - E3 ubiquitin ligase - mediates ubiquitination & subsequent proteasomal degradation of target proteins. - triggers the ubiquitin-mediated degradation of a) proteins involved in transcription regulation - POU2AF1, PML, NCOR1 b) cell surface receptor(s) - DCC c) antiapoptotic protein(s) - BAG1 d) protein(s) involved in synaptic vesicle function in neurons - SYP - role in: a) apoptosis b) tumor suppression c) cell cycle d) transcription e) signaling processes - has some overlapping function with SIAH1 - triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not Structure: - the RING-type zinc finger domain is essential for ubiquitin ligase activity Compartment: cytoplasmic; predominantly, nuclear partially Expression: widely expressed at low level.

General

E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein zinc finger protein

Properties

SIZE: entity length = 324 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: RING-finger {80-115} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Zn finger C2HC-type SITE: 136-161 EFFECTOR-BOUND: Zn+2 MOTIF: Zn+2-binding site SITE: 138-138 Zn+2-binding site SITE: 145-145 Zn+2-binding site SITE: 157-157 Zn+2-binding site SITE: 161-161 active site Zinc finger NAME: Zinc finger SITE: 166-192 EFFECTOR-BOUND: Zn+2 MOTIF: Zn+2-binding site SITE: 168-168 Zn+2-binding site SITE: 175-175 Zn+2-binding site SITE: 187-187 Zn+2-binding site SITE: 192-192

Database Correlations

OMIM 602213 UniProt O43255 Pfam PF03145 Entrez Gene 6478 Kegg hsa:6478

References

UniProt :accession O43255