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short stature

Etiology: - malnutrition may contribute - celiac sprue Epidemiology: -> 0.1-2.5% of the population Genetics: - associated with defects in GHR - associated with defects in GHSR - associated with defects in SHOX [3] Clinical manifestations: - subnormal rate of growth - height below the third percentile for chronological age - behavior & intelligence is normal Management: 1) none indicated 2) growth hormone increases size, but no evidence it improves outcomes

General

sign/symptom

Database Correlations

OMIM correlations

References

  1. Journal Watch 24(7):57, 2004 - Wheeler PG et al Arch Pediatr Adolesc Med 158:246, 2004 PMID: 14993082
  2. OMIM :accession 604271
  3. OMIM :accession 300582
  4. Allen DB and Cuttler L. Clinical practice. Short stature in childhood--challenges and choices. N Engl J Med 2013 Mar 28; 368:1220 PMID: 23534561 http://www.nejm.org/doi/full/10.1056/NEJMcp1213178