SH3 domain GRB2-like protein B1 (endophilin-B1, Bax-interacting factor 1, Bif-1, SH3GLB1)

Function: 1) lysophosphatidic acid acyltransferase activity 2) activation of caspases & apoptosis 3) binds DNM1, HD, AMPH & BIN1 4) binds BAX, induction of apoptosis augments BAX binding Structure: - homodimer & heterodimer with SH3GLB2 - belongs to the endophilin family - contains 1 BAR domain - contains 1 SH3 domain Compartment: - cytoplasm, peripheral membrane, internal membranes Alternative splicing: named isoforms=2 Expression: - expressed in heart, skeletal muscle, kidney, placenta > brain, colon, thymus, spleen, liver, small intestine, lung, peripheral blood leukocytes Uncertain whether Met-1 or Met-4 is the initiator

General

acyltransferase endophilin family protein

Properties

SIZE: MW = 41 kD entity length = 365 aa COMPARTMENT: cytoplasm MOTIF: BAR {27-261} MOTIF: coiled coil {155-195} src homology 3 [SH3] domain SITE: 305-365

Database Correlations

UniProt Q9Y371 PFAM correlations Entrez Gene 51100

References

UniProt :accession Q9Y371