small G protein signaling modulator 3; RUN & TBC1 domain-containing protein 3, Rab-GTPase-activating protein-like protein; RabGAPLP; Merlin-associated protein (SGSM3, MAP, RABGAPLP, RUTBC3)

Function: - may play a cooperative role in NF2-mediated growth suppression of cells - may act as a modulator of small G protein RAB- & RAP-mediated neuronal signal transduction & vesicular transportation pathways - interacts with GJA1 - interaction with GJA1 induces its degradation (putative) - interacts via its RUN domain with the C-terminal region of NF2 - interacts with RAB3, RAB4, RAB5, RAB8, RAP1A, RAP1B, RAP2A & RAP2B Structure: - belongs to the small G protein signaling modulator family - contains 1 Rab-GAP TBC domain - contains 1 RUN domain - contains 1 SH3 domain Alternative splicing: named isoforms=2

Properties

SIZE: entity length = 749 aa MW = 85 kD MOTIF: rab-GAP domain NAME: rab-GAP domain SITE: 114-305 phosphorylation site coiled coil {415-439} src homology 3 [SH3] domain SITE: 480-539 RUN {555-718}

Database Correlations

UniProt Q96HU1 PFAM correlations

References

UniProt :accession Q96HU1