splicing factor, arginine/serine-rich 19; serine arginine-rich pre-mRNA splicing factor SR-A1; SR-A1, SR-related-CTD-associated factor; (SCAF1, SCAF, SFRS19, SRA1)

Function: - may function in pre-mRNA splicing (putative) - interacts with POLR2A Structure: belongs to the splicing factor SR family Compartment: nucleus (probable) Expression: - ubiquitous - highly expressed in fetal brain & liver - poorly expressed in salivary gland, heart, skin & ovary - up-regulated by estrogens, androgens & glucocorticoids Pathology: - over expressed in colorectal carcinomas & ovarian cancers

General

phosphoprotein splicing factor; snRNP-associated protein

Properties

SIZE: entity length = 1312 aa MW = 139 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 184-267 MOTIF: proline residue (SEVERAL) serine-rich region {191-207} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S239} glutamate-rich region {268-288} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 380-441 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S498} Ser phosphorylation site {S500} Ser phosphorylation site {S526} RNA-binding motif FOR-BINDING-OF: ribonucleic acid serine-rich region {534-828} MOTIF: serine residue (SEVERAL) arginine-rich region {556-654} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S719} Ser phosphorylation site {S734} Ser phosphorylation site {S738} Ser phosphorylation site {S872} Ser phosphorylation site {S874} lysine-rich region {896-926} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S933} Ser phosphorylation site {S941} Ser phosphorylation site {S965} Thr phosphorylation site {T976} Thr phosphorylation site {T989} glutamate-rich region {1009-1039} MOTIF: glutamate residue (SEVERAL) POLR2A interaction {1187-1312} MOTIF: proline-rich region SITE: 1284-1311 MOTIF: proline residue (SEVERAL)

References

UniProt :accession Q9H7N4