splicing factor arginine/serine-rich 10; transformer-2-beta; HTRA2-beta; transformer 2 protein homolog (SFRS10, TRA2B)

Function: 1) sequence-specific RNA-binding protei 2) pre-mRNA splicing 3) interacts with SAFB1, RNPS1, phosphorylated FUSIP1 4) binds to A3 enhancer proteins SRp75, SRp55, SRp40, SRp30 Compartment: nuclear Expression: - expressed in heart, skeletal muscle, pancreas > kidney, placenta, brain > kidney, liver

General

phosphoprotein splicing factor arginine/serine-rich (SFRS)

Properties

SIZE: MW = 34 kD entity length = 288 aa COMPARTMENT: cell nucleus MOTIF: arginine/serine-rich region (RS domain) {31-113} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL) RRM {118-196} Linker {193-230} arginine/serine-rich region (RS domain) {231-287} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL) Ser phosphorylation site {S264} Ser phosphorylation site {S266}

Database Correlations

OMIM 602719 UniProt P62995 Pfam PF00076

References

UniProt :accession P62995