splicing factor 3A subunit 3 (spliceosome associated protein 61, SAP 61, SF3a60, SF3A3)

Function: - subunit of the splicing factor SF3A - identified in the spliceosome C complex - interacts with SF3A1, through its N-terminal region Structure: - belongs to the SF3A3 family - contains 1 matrin-type Zn⁺² finger Compartment: nucleus speckle Expression: ubiquitous

General

protein subunit splicing factor; snRNP-associated protein

Properties

SIZE: entity length = 501 aa MW = 59 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl Thr phosphorylation site {T277} glutamate-rich region {354-362} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S365} Ser phosphorylation site {S367} Ser phosphorylation site {S369} Zn finger matrin-type NAME: Zn finger matrin-type SITE: 406-437 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y414}

Database Correlations

OMIM 605596 UniProt Q12874 Kegg hsa:1094

References

UniProt :accession Q12874