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sex hormone-binding globulin (SHBG) in serum

Reference interval: - 13-71 nmol/L (adult male) - 18-114 nmol/L (non-pregnant adult female) Increases: - hyperthyroidism - estrogen excess - thyroid hormone administration - anorexia nervosa - pregnancy - cirrhosis - aging Decreases: - hypothyroidism - testosterone excess - hirsutism - obesity - nephrotic syndrome - polycystic ovary syndrome Notes: - lower serum SHBG associated with modest reduction in all-cause mortality (RR=0.83-0.94) [11]

Related

sex hormone-binding globulin; SHBG; Sex steroid-binding protein; SBP; testis-specific androgen-binding protein; ABP; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; TeBG (SHBG)

General

globulin in body fluid

References

  1. Interpretation of Diagnostic tests, 8th edition, Wallach J, Lippincott, Williams & Wilkens, Philadelphia, 2007, pg 17
  2. Clinical Guide to Laboratory Tests, 4th edition, HB Wu ed, WB Saunders, Philadelphia, 2006
  3. Panel of 5 tests Laboratory Test Directory ARUP: 70102
  4. Panel of 4 tests Laboratory Test Directory ARUP: 70109
  5. Panel of 3 tests Laboratory Test Directory ARUP: 70111
  6. Panel of 3 tests Laboratory Test Directory ARUP: 81056
  7. Panel of 3 tests Laboratory Test Directory ARUP: 81057
  8. Mini Panel of 2 tests: Sex Hormone Binding Globulin 1 . Testosterone, Free LC-MS/MS Laboratory Test Directory ARUP: 81059
  9. Sex Hormone Binding Globulin Laboratory Test Directory ARUP: 99375
  10. Panel of 5 tests Laboratory Test Directory ARUP: 2001763
  11. Yeap BB, Marriot RJ, Dwivedi G et al Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men: Individual Participant Data Meta-analyses. Ann Intern Med 2024. May 14. PMID: 38739921 Review. https://www.acpjournals.org/doi/10.7326/M23-2781