Search
sevoflurane (Ultane)
Tradename: Ultane.
Indications:
- induction & maintenance of general anesthesia (inhalation)
Contraindications: Caution:
- use with adequate ventilation; potentially toxic breakdown products
Dosage: Liquid for inhalation: 250 mL.
Monitor:
1) renal function
2) blood pressure
3) temperature
4) heart rate
5) neuromuscular function
6) oxygen saturation
7) endtidal CO2
8) endtidal sevoflurane concentrations
Adverse effects:
1) common (> 1%)
- nausea/vomiting (18-25%)
2) uncommon (< 1%)
- bradycardia, hypotension, tachycardia, hypertension, agitation, headache, somnolence, dizziness, fever, early emergence movement, hypothermia, increased salivation, laryngospasm, airway obstruction, breath holding, increased cough, apnea, shivering
3) other
- malignant hyperthermia
- fluoride neuropathy
- increased cerebral blood flow & increased intracranial pressure
Drug interactions:
1) 50% N2O reduces minimum alveolar concentration (MAC) equivalent dose of sevoflurane by 50% in adults & 25% in children
2) benzodiazepines & opioids reduces minimum alveolar concentration (MAC) equivalent dose of sevoflurane
Laboratory:
- sevoflurane gas delivered.total volume
- sevoflurane liquid delivered.total volume
General
general anesthetic inhalation
Database Correlations
PUBCHEM cid=5206
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Department of Veterans Affairs, VA National Formulary