Set1/Ash2 histone methyltransferase (HMT) complex

Function: - specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated Structure: - subunits include: - catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 & DPY30

Properties

COMPARTMENT: cell nucleus MOTIF: active site SUBUNITS: histone-lysine N-methyltransferase H3 lysine-4 specific SET1 COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 84-172 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif serine-rich region {244-362} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 383-654 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S468} Ser phosphorylation site {S470} glutamate-rich region {899-1010} MOTIF: glutamate residue (SEVERAL) serine-rich region {1011-1062} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 1071-1194 MOTIF: proline residue (SEVERAL) HCFC1-binding motif (HBM) {1299-1303} glutamate-rich region {1334-1375} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 1403-1417 MOTIF: proline residue (SEVERAL) SET domain {1567-1689} post-SET domain {1691-1707} Set1/Ash2 histone methyltransferase complex subunit ASH2 COMPARTMENT: cell nucleus MOTIF: Zn finger C4-type SITE: 117-150 EFFECTOR-BOUND: Zn+2 B30.2/SPRY {360-583} WD repeat-containing protein 5 COMPARTMENT: cell nucleus MOTIF: WD repeat {43-82} WD repeat {85-126} MOTIF: aspartate residue {107} WD repeat {128-168} MOTIF: phenylalanine residue {133} WD repeat {169-208} WD repeat {212-253} WD repeat {256-296} MOTIF: phenylalanine residue {263} Ser phosphorylation site {S267} WD repeat {299-333} MOTIF: glutamate residue {322} retinoblastoma binding protein 5 COMPARTMENT: cell nucleus MOTIF: WD repeat {22-63} WD repeat {64-103} WD repeat {148-188} MOTIF: Ser phosphorylation site {S182} Thr phosphorylation site {T193} WD repeat {196-235} WD repeat {249-291} MOTIF: Thr phosphorylation site {T252} WD repeat {293-331} Ser phosphorylation site {S350} Ser phosphorylation site {S388} Ser phosphorylation site {S389} Ser phosphorylation site {S497} CpG-binding protein COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S6} Ser phosphorylation site {S19} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 28-76 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 160-209 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T227} acidic region {256-317} MOTIF: acidic residue (SEVERAL) lysine-rich region {321-359} MOTIF: lysine residue (SEVERAL) coiled coil {422-474}

References

UniProt :accession O15047

Components

CpG-binding protein; PHD finger & CXXC domain-containing protein 1; CXXC finger protein 1 (CXXC1, CGBP, PCCX1, PHF18) histone-lysine N-methyltransferase H3 lysine-4 specific SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET-domain-containing protein 1A (SETD1A, KIAA0339, SET1) retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3) Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L) WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)