histone-lysine N-methyltransferase H3 lysine-4 specific SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET-domain-containing protein 1A (SETD1A, KIAA0339, SET1)

Function: 1) methylates Lys-4 of histone H3 2) methylation specific for when part of HMT complex is methylated, except when Lys-9 residue already methylated 3) component of Set1/Ash2 histone methyltransferase complex (HMT complex) Compartment: nucleus

General

histone N-methyltransferase SET domain-containing protein

Properties

SIZE: MW = 186 kD entity length = 1707 aa COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 84-172 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif serine-rich region {244-362} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 383-654 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S468} Ser phosphorylation site {S470} glutamate-rich region {899-1010} MOTIF: glutamate residue (SEVERAL) serine-rich region {1011-1062} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 1071-1194 MOTIF: proline residue (SEVERAL) HCFC1-binding motif (HBM) {1299-1303} glutamate-rich region {1334-1375} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 1403-1417 MOTIF: proline residue (SEVERAL) SET domain {1567-1689} post-SET domain {1691-1707}

Database Correlations

OMIM 611052 UniProt O15047 PFAM correlations Entrez Gene 9739 Kegg hsa:9739 ENZYME 2.1.1.43

References

UniProt :accession O15047