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zinc (Zn+2) in serum/plasma

Indications: - assessment of zinc deficiency - assessment of zinc toxicity Reference interval: - 60-130 ug/dL (9-20 umol/L) Clinical significance: - 75-88% of Zn+2 in whole blood is in erythrocytes - levels in erythrocytes 15 times that of plasma - no body stores of zinc Decreases: - zinc deficiency - dwarfism - acrodermatitis enteropathica - acute tissue injury - acute myocardial infarction - chronic liver disease - severe hepatocellular disease - sickle cell disease - some cancers - colon cancer - lung cancer - metastatic cancer to liver - leukemias - lymphomas - parenteral nutrition (Zn+2-deficient, several weeks) - hypoalbuminemia* - stress - infection - typhoid fever - pulmonary tuberculosis - pregnancy - malnutrition or decreased Zn+2 absorption - celiac disease - pica (Zn+2-binding agents) - burns - thalassemia major - pharmaceuticals - estrogens, cisplatin, corticosteroids, interferon, phenytoin, thiazides * 50% of serum Zn+2 is bound to albumin Increases: - zinc toxicity - acidic beverages & foods in Zinc containers - excessive Zinc supplementation - high-dose zinc therapy may result in copper deficiency & acquired sideroblastic anemia - hemodialysis against a diasylate high in Zn+2 - pharmaceuticals - chlorthalidone, penicillamine - osteosarcoma of bone - arteriosclerosis, coronary artery disease - anemia Method: - measurement by atomic absorption spectroscopy Specimen: - serum or plasma - fasting morning specimen - Collect in acid-washed polypropylene container, zinc-free vacuum tubes or metal-free glass. Avoid hemolysis. - Separate from cells within 45 minutes Interferences: - rubber stoppers on vacutainers & storage containers may be a significant source of contamination

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zinc deficiency Zn+2

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zinc (Zn+2) in body fluid

References

  1. Bakerman's ABC's of Interpretive Laboratory Data Bakerman S, Bakerman P, Strausbach P Interpretive Laboratory Data In, Scottsdale 2002
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Zinc, Serum Laboratory Test Directory ARUP: 20097