Search
insulin-like growth factor (IGF)-1 or somatomedin C in serum
Indications:
1) diagnosis of & assessment of severity of acromegaly
2) assessement of response of dwarfism to growth hormone therapy#
3) assessment of effectiveness of nutritional repletion
-> may be superior to prealbumin
# children with low levels of IGF-1 may need growth hormone stimulation test to establish the diagnosis of growth hormone deficiency
Reference interval:
- 135-440 ng/mL, age = 26-85 years
- Male: 202-433 ng/mL, age = 19-25 years
- Female: 231-550 ng/mL, age = 19-25 years
- Male: 134-836 ng/mL, age = 15-18 years
- Female: 152-860 ng/mL, age = 15-18 years
- Male: 165-616 ng/mL, age = 13-14 years
- Females : 286-660 ng/mL, age = 13-14 years
- Male: 136-440 ng/mL, age = 11-12 years
- Female: 191-462 ng/mL, age = 11-12 years
- Male: 136-385 ng/mL, age = 7-10 years
- Female: 123-396 ng/mL, age = 7-10 years
- Male: 16-288 ng/mL, age = 3-6 years
- Female: 70-316 ng/mL, age = 3-6 years
- Male: 31-160 ng/mL, age = 1-2 years
- Female: 11-206 ng/mL, age = 1-2 years
amniotic fluid (< 12 weeks): undetectable
* Levels are higher in pregnancy
Increases:
- acromegaly
Decreases:
1) high-dose estrogens
2) dwarfism
3) hypopituitarism
4) hypothyroidism
5) malnutrition
- after refeeding, high levels of growth hormone decrease & low levels of IGF-1 increase
6) anorexia
7) emotional deprivation syndrome
8) cirrhosis of the liver
9) sarcopenia [3,4,5]
Specimen:
- serum
- freeze immediately
- stable for 30 days
Related
acromegaly
growth hormone (GH) stimulation test
growth hormone (somatotropin) in serum
insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
General
insulin-like growth factor (IGF)-1 or somatomedin C in serum/plasma/blood
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- IGF-1 (Insulin-Like Growth I)
Laboratory Test Directory ARUP: 70125
- Ferrari U, Schmidmaier R, Jung T et al
IGF-I/IGFBP3/ALS Deficiency in Sarcopenia: Low GHBP Suggests GH Resistance in a
Subgroup of Geriatric Patients.
J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1698-e1707.
PMID: 33378445
- Jiang JJ, Chen SM, Chen J, Wu L, Ye JT, Zhang Q.
Serum IGF-1 levels are associated with sarcopenia in elderly men but not in elderly women.
Aging Clin Exp Res. 2022 Oct;34(10):2465-2471.
PMID: 35962897
- Bian A, Ma Y, Zhou X, Guo Y, Wang W, Zhang Y, Wang X.
Association between sarcopenia and levels of growth hormone and insulin-like
growth factor-1 in the elderly.
BMC Musculoskelet Disord. 2020 Apr 7;21(1):214.
PMID: 32264885 PMCID: PMC7140321 Free PMC article.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7140321/