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dehydroepiandrosterone (DHEA) sulfate in serum/plasma

Reference interval: 1) males: 10-619 ug/dL (0.3-16.7 umol/L) a) 19-30 years: 125-619 ug/dL (3.4-16.7 umol/L) b) 31-50 years: 50-452 ug/dL (1.6-12.2 umol/L) c) 51-60 years: 20-413 ug/dL (0.5-11.1 umol/L) d) 61-83 years: 10-285 ug/dL (0.3-7.7 umol/L) 2) females: 12-781 ug/dL (0.8-21.1 umol/L) a) 19-30 years: 29-781 ug/dL (0.8-21.1 umol/L) b) 31-50 years: 12-379 ug/dL (0.4-10.2 umol/L) c) postmenopause: 30-260 ug/dL (0.8-7.0 umol/L) d) one size fits all: 0.6-3.3 ug/mL (3.5-14.9 umol/L) [2] Increases: 1) pharmaceutical agents -> clomiphene, danazol 2) clinical disorders a) females with hirsuitism & acne b) congenital adrenal hyperplasia c) adrenal cortex tumors - levels higher with adrenal carcinoma than adrenal adenoma - levels of serum DHEA-sulfate > 8 ug/mL diagnostic of androgen-producing adrenal carcinoma [2] d) Cushing's disease e) ectopic ACTH-producing tumors f) polycystic ovary syndrome Decreases: 1) pharmaceutical agents -> glucocorticoids 2) clinical disorders - adrenal insufficiency, primary or secondary 3) low serum DHEA-S levels predict cardiovascular events due to coronary artery disease (MI, acute coronary syndrome ..) in elderly men [5] - no association of serum DHEA-S & cardiovascular events due cerebrovascular disease (TIA, ischemic stroke) [5] * DHEA-sulfate serum levels decline progressively with aging. Serum levels provide an estimate of adrenal androgen production. Specimen: 1) serum or plasma (EDTA) 2) stable for 2 days at 4 degrees C 3) stable for 2 months at -20 degrees C

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dehydroepiandrosterone sulfate (DHEA-SO4)

General

dehydroepiandrosterone (DHEA) sulfate in body fluid

References

  1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  3. DHEAS Laboratory Test Directory ARUP: 70040
  4. Panel of 5 tests Laboratory Test Directory ARUP: 2001763
  5. Tivesten A et al. Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. J Am Coll Cardiol 2014 Oct 28; 64:1801 PMID: 25443702 http://www.sciencedirect.com/science/article/pii/S0735109714059403 - Sutton NR and Pinsky DJ. Sex steroid as a new oracle to predict cardiovascular risk. J Am Coll Cardiol 2014 Oct 28; 64:1811. PMID: 25443703 http://www.sciencedirect.com/science/article/pii/S0735109714059397

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dehydroepiandrosterone sulfate (DHEA-S)/cortisol in serum/plasma