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serrated polyposis syndrome; hyperplastic polyposis syndrome
Diagnostic criteria:
1 of 3 criteria:
1) > 5 histologically identified hyperplastic polyps or serrated adenomas proximal to the sigmoid colon
- 2 of these polyps must be > 10 mm in diameter
2) >= 1 hyperplastic polyp or serrated adenomas proximal to the sigmoid colon in an individual with at least 1 1st degree relative with hyperplastic polyps
3) > 20 hyperplastic polyps or serrated adenomas distributed throughout the colon [2]
Genetics:
- no genetic basis established
Special laboratory:
- colonoscopy surveillance yearly [2]
Complications:
- increased risk of colon carcinoma
- no increased risk of extra-intestinal cancer
- mean age of colon cancer diagnosis is 56 years [2]
- incidence of colon cancer during 5 year follow-up is 7% [2]
Related
hyperplastic polyp
serrated colorectal polyp; serrated adenoma
General
intestinal polyposis syndrome
References
- Chow E et al,
Hyperplastic polyposis syndrome: Phenotypic presentation and the
role of MBD4 and MYH.
Gastroenterology 2006, 131:30
PMID: 16831587
- Medical Knowledge Self Assessment Program (MKSAP) 17, 18.
American College of Physicians, Philadelphia 2015, 2018