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SERPINE1 gene mutation

Clinical significance: - defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency* * heterozygousity of null SERPINE1 allele associated with longevity [2]

Related

plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)

General

gene mutation testing; gene mutation analysis

References

  1. Loinc
  2. Khan SS, Shah SJ, Klyachko E et al A null mutation in SERPINE1 protects against biological aging in humans. Science Advances. 15 Nov 2017:Vol. 3, no. 11, eaao1617 PMID: 29152572 Free PMC Article http://advances.sciencemag.org/content/3/11/eaao1617.full