serpin B3; squamous cell carcinoma antigen 1; SCCA-1; protein T4-A (SERPINB3, SCCA, SCCA1)

Function: - may act as a protease inhibitor to modulate the host immune response against tumor cells Structure: belongs to the serpin family, Ov-serpin subfamily Compartment: - cytoplasm - seems to also be secreted in plasma by cancerous cells but at a low level Alternative splicing: named isoforms=2 Expression: - squamous cells - expressed in some hepatocellular carcinoma (at protein level) - expression is closely related to cellular differentiation in both normal & malignant squamous cells

General

glycoprotein serine protease inhibitor; serpin

Properties

SIZE: entity length = 390 aa MW = 45 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl serpin motif FOR-BINDING-OF: serine protease glycosylation site reactive S-S {354-355} INHIBITS: serine protease

Database Correlations

OMIM 600517 UniProt P29508 Pfam PF00079 Entrez Gene 6317 Kegg hsa:6317

References

UniProt :accession P29508