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serotonin [5HT]-2C receptor; 5-hydroxytryptamine receptor 2C; 5-HTR2C; 5-HT-2C; 5-HT2C; 5HT-1C; serotonin receptor 2C (HTR2C, HTR1C)
Function:
- one of several receptors for 5-hydroxytryptamine (serotonin)
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- interacts with MPDZ
- tonic inhibition of a neuronal excitatory network [2] (see pathology)
Structure:
- The PDZ domain-binding motif is involved in the interaction with MPDZ
- belongs to the G-protein coupled receptor 1 family
- N-glycosylated
Compartment: cell membrane
Genetics:
- RNA editing
- modified positions=156, 158, 160
- partially edited
- RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting a role in modulation of serotonergic neurotransmission in the CNS
Polymorphism:
- position 23 is polymorphic
- frequencies in unrelated Caucasians are 0.87 for Cys & 0.13 for Ser
Comparative biology:
- 5-HT 2C receptor-deficient mice are
a) overweight as a result of abnormal control of feeding behavior
b) prone to spontaneous death from seizures suggesting a role in tonic inhibition of a neuronal excitatory network [2]
Laboratory:
- HTR2C gene mutation
- HTR2A+HTR2C gene mutation
Note:
- previously, termed 5-HT 1C receptor [2]
General
glycoprotein
serotonin [5HT]-2 receptor
Properties
SIZE: entity length = 458 aa
MW = 52 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-52}
MOTIF: N-glycosylation site {N39}
transmembrane domain {53-78}
cytoplasmic loop {79-89}
transmembrane domain {90-110}
exoplasmic loop {111-127}
MOTIF: cysteine residue {C127}
MODIFICATION: cysteine residue {C207}
transmembrane domain {128-150}
cytoplasmic loop {151-170}
transmembrane domain {171-193}
exoplasmic loop {194-213}
MOTIF: cysteine residue {C207}
MODIFICATION: cysteine residue {C127}
transmembrane domain {214-235}
cytoplasmic loop {236-311}
transmembrane domain {312-333}
exoplasmic loop {334-348}
transmembrane domain {349-371}
cytoplasmic domain {372-458}
MOTIF: PDZ recognition motif
NAME: PDZ recognition motif
SITE: 456-458
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 312861
UniProt P28335
Pfam PF00001
Entrez Gene 3358
Kegg hsa:3358
References
- UniProt :accession P28335
- Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH,
Dallman MF, Julius D.
Eating disorder and epilepsy in mice lacking 5-HT2c serotonin
receptors.
Nature. 1995 Apr 6;374(6522):542-6.
PMID: 7700379
- Entrez Gene :accession 3358