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serotonin [5HT]-2 receptor
serotonin-2-receptors 2A-2C.
Adverse effects:
1) hallucinogenic effects of LSD & other psychedelics
2) sexual dysfunction (impotence)
3) extrapyramidal symptoms
4) anxiety
5) insomnia
Interactions
molecular events
Specific
serotonin [5HT]-2A receptor; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2; serotonin receptor 2A (HTR2A, HTR2)
serotonin [5HT]-2B receptor; 5-hydroxytryptamine receptor 2B; 5-HT-2B; serotonin receptor 2B (HTR2B)
serotonin [5HT]-2C receptor; 5-hydroxytryptamine receptor 2C; 5-HTR2C; 5-HT-2C; 5-HT2C; 5HT-1C; serotonin receptor 2C (HTR2C, HTR1C)
General
serotonin [5HT] receptor
G-protein coupled receptor; serpentine receptor
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {N-TERMINAL}
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cytoplasmic domain {C-TERMINAL}
Database Correlations
OMIM 182135
MORBIDMAP 182135
References
- Felder CC, Kanterman RY, Ma AL, Axelrod J.
Serotonin stimulates phospholipase A2 and the release of
arachidonic acid in hippocampal neurons by a type 2 serotonin
receptor that is independent of inositolphospholipid
hydrolysis.
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2187-91.
PMID: 2315313