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serotonin; 5-hydroxytryptamine
Function:
- biogenic hormone derived from tryptophan.
- functions as a neurotransmitter, a hormone, & a mitogen
- serotonin within the pineal gland is used for synthesis of melatonin.
- serotonin inhibits response of the suprachiasmatic nucleus to light
- metabolism of serotonin is primarily by MAO-A, but MAO-B may play a minor role when serotonin is present in high concentrations
Expression:
- serotoninergic neurons are found in the raphe nuclei & contain different cotransmitters
- platelets & mast cells contain serotonin
Physiology:
- serotonin may play a role in dreaming
Pharmacology:
- inhibition of re-uptake is a major strategy for treatment of depression, anxiety & obsessive-compulsive disorder (OCD)
- selective serotonin-reuptake inhibitors (SSRI) are used as antidepressants
Pathology:
- serotonin appears to be involved in regulation of anxiety & impulsive behavior
Interactions
molecular events
Related
5-OH indoleacetic acid
indole metabolism
Na+-dependent serotonin transporter; 5HT transporter; 5HTT; solute carrier family 6 member 4 (SLC6A4, HTT, SERT)
selective serotonin reuptake inhibitor (SSRI)
serotonin Ag in tissue
serotonin [5HT] receptor
Specific
N'acetyl-serotonin
N'methyl-serotonin
General
5-hydroxyindole
neurotransmitter
tryptamine
vasoconstrictor
Database Correlations
PUBCHEM cid=5202