Search
serologically defined colon cancer antigen 8; antigen NY-CO-8; centrosomal colon cancer autoantigen protein; hCCCAP (SDCCAG8, CCCAP, NPHP10, HSPC085)
Function:
- role in the establishment of cell polarity & epithelial lumen formation (putative)
- may play a role in ciliogenesis
- interacts with OFD1
Structure: homodimer
Compartment:
- cytoplasm, cytoskeleton, centrosome, centriole, cell junction
- located at the distal ends of both centrioles & colocalizes to centrosomes throughout the cell cycle
- isoform 2: cytoplasm
Alternative splicing: named isoforms=4
Expression:
- expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon
Pathology:
- expressed in renal cancer
- defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7
General
other protein
Properties
SIZE: entity length = 713 aa
MW = 83 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {129-175}
Sufficient for homodimerization {216-713}
MOTIF: coiled coil {223-273}
coiled coil {348-707}
Mediates interaction with OFD1 {533-713}
glutamine-rich region {534-692}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM correlations
UniProt Q86SQ7
Entrez Gene 10806
Kegg hsa:10806
References
UniProt :accession Q86SQ7