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serologic test for syphilis
Two types of serologic tests are used for the diagnosis of syphilis: non treponemal & treponemal assays.
Clinical significance:
- a positive treponemal assay with a negative non-treponemal assay (RPR or VDRL) is consistent with treated syphilis [3]*
* check for history of treated syphilis in patient medical history
Related
syphilis
Specific
nontreponemal serologic test for syphilis
treponemal serologic test for syphilis
General
serology for infectious agent
References
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996, pg 1186
- Park IU et al.
Screening for syphilis with the treponemal immunoassay:
Analysis of discordant serology results and implications
for clinical management.
J Infect Dis 2011 Nov 1; 204:1297
PMID: 21930610
- Hoover KW and Radolf JD.
Serodiagnosis of syphilis in the recombinant era:
Reversal of fortune.
J Infect Dis 2011 Nov 1; 204:1295.
PMID: 21921204
- Medical Knowledge Self Assessment Program (MKSAP) 18, 19.
American College of Physicians, Philadelphia 2018, 2021