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serine/threonine protein kinase DCLK1; doublecortin domain-containing protein 3A; doublecortin-like & CAM kinase-like 1; doublecortin-like kinase 1 (DCLK1, DCAMKL1, DCDC3A, KIAA0369)
Function:
- probable kinase
- may be involved in a Ca+2- signaling pathway controlling neuronal migration in the developing brain
- may also participate in functions of the mature nervous system
ATP + a protein = ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
- contains 2 doublecortin domains
- contains 1 protein kinase domain
Alternative splicing:
- named isoforms=4
- type A (AS & AL) & type B (BS & BL) isoforms differ respectively by the presence or absence of the doublecortin domain
- an alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms
- additional isoforms seem to exist
Expression:
- in fetal tissues
- highly expressed in brain
- detectable in lung & liver
- not expressed in kidney
- in adult tissues
- expressed ubiquitously in the brain
- detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine & colon
- type A isoforms seem to be expressed predominantly in fetal brain
- type B isoforms are expressed abundantly in both fetal & adult brain
- up-regulated in response to enterovirus 71 (EV71) infection (at protein level)
General
doublecortin domain-containing protein (DCDC)
serine/threonine kinase
Properties
SIZE: entity length = 740 aa
MW = 82 kD
MOTIF: Ser phosphorylation site {S32}
Ser phosphorylation site {S36}
doublecortin domain {57-143}
doublecortin domain {186-269}
serine-rich region {288-340}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S305}
Ser phosphorylation site {S307}
Ser phosphorylation site {S330}
Ser phosphorylation site {S332}
Ser phosphorylation site {S334}
Thr phosphorylation site {T336}
Ser phosphorylation site {S337}
Ser phosphorylation site {S364}
Ser phosphorylation site {S376}
kinase domain
SITE: 390-647
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 396-404
ATP-binding site
NAME: ATP-binding site
SITE: 419-419
Tyr phosphorylation site {Y493}
aspartate residue {D511}
Tyr phosphorylation site {Y520}
arginine-rich region {698-701}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S722}
Ser phosphorylation site {S726}
STATE: active state
Database Correlations
OMIM 604742
UniProt O15075
PFAM correlations
Entrez Gene 9201
Kegg hsa:9201
ENZYME 2.7.11.1
References
UniProt :accession O15075