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serglycin; secretory granule proteoglycan core protein; platelet proteoglycan core protein; P.PG; hematopoietic proteoglycan core protein (SRGN, PRG, PRG1)
Function:
- proteoglycan core protein of heparin [3]
- role in formation of mast cell secretory granules & mediates storage of various compounds in secretory vesicles
- required for storage of some proteases in both connective tissue & mucosal mast cells & for storage of granzyme B in T lymphocytes
- role in localizing neutrophil elastase in azurophil granules of neutrophils
- mediates processing of MMP2
- role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis
- regulates the secretion of TNF-alpha & may also regulate protease secretion
- inhibits bone mineralization
- binds to activated CD44 & to GZMB
Structure:
- O-glcosylated
- contains chondroitin sulfate & heparan sulfate (putative)
- belongs to the serglycin family
Compartment:
- cytoplasmic granule (putative)
- secreted, extracellular space
- Golgi
- found in mast cell granules & in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation
- located to Golgi apparatus during neutrophil differentiation
Expression:
- secreted from activated cytolytic T lymphocytes
- secreted constitutively by endothelial cells & macrophages
- induced by EBV
General
proteoglycan core protein
Properties
SIZE: entity length = 158 aa
MW = 18 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: signal sequence {1-27}
cysteine residue {C40}
MODIFICATION: cysteine residue {C49}
cysteine residue {C49}
MODIFICATION: cysteine residue {C40}
glycocalyx
MODIFICATION: glycosaminoglycan
9 X 2 AA tandem repeats of [SF]-G {94-111}
MOTIF: consensus repeat {94-95}
Ser glycosylation site {S94}
consensus repeat {96-97}
Ser glycosylation site {S96}
consensus repeat {98-99}
consensus repeat {100-101}
Ser glycosylation site {S100}
consensus repeat {102-103}
Ser glycosylation site {S102}
consensus repeat {104-105}
Ser glycosylation site {S104}
consensus repeat {106-107}
Ser glycosylation site {S106}
consensus repeat {108-109}
Ser glycosylation site {S108}
consensus repeat {110-111}
Ser glycosylation site {S110}
Database Correlations
OMIM 177040
UniProt P10124
Pfam PF04360
Entrez Gene 5552
Kegg hsa:5552
References
- UniProt :accession P10124
- Ruoslahti E, Yamaguchi Y.
Proteoglycans as modulators of growth factor activities.
Cell. 1991 Mar 8;64(5):867-9. Review.
PMID: 2001586
- Salmivirta M, Lidholt K, Lindahl U.
Heparan sulfate: a piece of information.
FASEB J. 1996 Sep;10(11):1270-9. Review.
PMID: 8836040
Component-of
heparan proteoglycan