septin-4; bradeion beta; brain protein H5; CE5B3 beta; cell division control-related protein 2; hCDCREL-2; cerebral protein 7; peanut-like protein 2; apoptosis-related protein in the TGF-beta signaling pathway (SEPT4, PNUTL2, SEP4, hucep-7)

Function: - filament-forming cytoskeletal GTPase (putative) - may play a role in cytokinesis (putative) - may play a role in platelet secretion - isoform 6, but not the other isoforms, is required for induction of cell death mediated by TGF-beta & by other apoptotic stimuli - septins polymerize into heterooligomeric protein complexes that form filaments, & can associate with cellular membranes, actin filaments & microtubules - GTPase activity is required for filament formation (putative) - interacts with SEPT8 - in a mesenchymal cell line, interacts with SEPT9 isoform 2 Structure: belongs to the septin family Compartment: - cytoplasm (putative) - cytoskeleton (putative) - in platelets, found in areas surrounding alpha-granules - isoform 6: - mitochondrion, nucleus - predominantly localized in the mitochondria under resting conditions - translocates into the nucleus after TGF-beta treatment & induction of apoptosis Alternative splicing: named isoforms=6 Expression: - widely expressed in adult & fetal tissues - highest expression in adult brain (at protein level), heart, liver & adrenal gland & fetal heart, kidney, liver & lung - also expressed in colorectal cancers & malignant melanomas - expressed in platelets

General

phosphoprotein septin

Properties

SIZE: entity length = 478 aa MW = 55 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: GTP-binding site SITE: 151-158 GTP-binding site SITE: 185-185 GTP-binding site SITE: 211-211 GTP-binding site SITE: 290-298 Ser phosphorylation site {S325} GTP-binding site SITE: 348-348 GTP-binding site SITE: 363-363 coiled coil {447-478}

Database Correlations

OMIM 603696 UniProt O43236 Pfam PF00735 Entrez Gene 5414 Kegg hsa:5414

References

UniProt :accession O43236