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septin-1; LARP; peanut-like protein 3; serologically defined breast cancer antigen NY-BR-24 (SEPT1, DIFF6, PNUTL3)
Function:
- filament-forming cytoskeletal GTPase (putative)
- may play a role in cytokinesis (putative)
- Ser-248 & Ser-315 are probably phosphorylated by STK12
- septins polymerize into heterooligomeric protein complexes that form filaments
- the can associate with cellular membranes, actin filaments & microtubules
- GTPase activity is required for filament formation (putative)
- interacts with AURKB/STK12
Structure:
- belongs to the septin family
Compartment:
- cytoplasm (putative)
- cytoskeleton (putative)
- centrosome
- remains at the centrosomes & the nearby microtubules throughout mitosis
- localizes to the midbody during cytokinesis
Alternative splicing: named isoforms=2
Expression:
- expressed at high levels in lymphoid & hematopoietic tissues
General
phosphoprotein
septin
Properties
SIZE: entity length = 367 aa
MW = 42 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 32-39
GTP-binding site
SITE: 66-66
GTP-binding site
SITE: 92-92
GTP-binding site
SITE: 171-179
GTP-binding site
SITE: 229-229
GTP-binding site
SITE: 245-245
Ser phosphorylation site {S248}
Ser phosphorylation site {S307}
Ser phosphorylation site {S315}
Database Correlations
OMIM 612897
UniProt Q8WYJ6
Pfam PF00735
Entrez Gene 1731
Kegg hsa:1731
References
- UniProt :accession Q8WYJ6
- Entrez Gene :accession 1731