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senna; sennosides,(Senokot, Geri-kot)

Tradename: Senokot. Contains 1) sennosides A & B 2) glucosides of rhein & chrysophanic acid Indications: - relief of constipation - irritable bowel syndrome Dosage: 1) 10-15 mL PO QHS 2) 1-2 tablets daily as needed, titrate to control 3) maximum of 8 tablets/day given as 2 tabs QID Tabs: 187 mg senna concentrate [4] Suppositories: 652 mg Syrup: 218 mg/5 mL Pharmacokinetics: - onset of bowel relief is 6-12 hours, but may take as long as 24 hours Adverse effects: - chronic senna use (> 4 months) may result in melanosis coli Mechanism of action: 1) mild stimulant laxative 2) contains a stool softener

General

laxative

Properties

MISC-INFO: elimination route LIVER pregnancy-category C safety in lactation ?

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Merck Index 12th ed. 1996
  4. Drug Facts and Comparisons, 1996 editions, Facts and Comparisons, St Louis
  5. Deprecated Reference

Component-of

Brazilian Diet Pill (Emagrece Sim, Body slim) polycarbophil/psyllium/senna psyllium/senna senna/sodium docusate; sennosides-docusate sodium; senokot-S, senna-S