tRNA-splicing endonuclease subunit Sen54 (tRNA-intron endonuclease Sen54, HsSen54, TSEN54, SEN54)

Function: 1) non-catalytic subunit of the tRNA-splicing endonuclease 2) also belongs to a complex containing isoform 2 of SEN2 3) phosphorylated upon DNA damage, probably by ATM or ATR Compartment: - nucleus, nucleolus (probable) - may be transiently localized in the nucleolus Alternative splicing: named isoforms=2

General

enzyme regulatory subunit phosphoprotein

Properties

SIZE: entity length = 526 aa MW = 59 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S230} Ser phosphorylation site {S235}

Database Correlations

OMIM 608755 MORBIDMAP 608755 UniProt Q7Z6J9 Kegg hsa:2839

References

UniProt :accession Q7Z6J9