tRNA-splicing endonuclease subunit sen34; leukocyte receptor cluster member 5; tRNA-intron endonuclease sen34; Hssen34 (TSEN34, LENG5, SEN34)

Function: - constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex - probably carries the active site for 3'-splice site cleavage Structure: - belongs to the tRNA-intron endonuclease family Compartment: - nucleus, nucleolus - may be transiently localized in the nucleolus Pathology: - defects in TSEN34 are the cause of pontocerebellar hypoplasia type 2C Genetics: - gene belongs to the leukocyte receptor cluster (LRC) present on 19q13.4

General

endonuclease enzyme catalytic subunit leukocyte receptor cluster member phosphoprotein

Properties

SIZE: entity length = 310 aa MW = 34 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S134} Ser phosphorylation site {S135} Ser phosphorylation site {S136} tyrosine residue {Y247} histidine residue {H255} lysine residue {K286}

Database Correlations

OMIM correlations UniProt Q9BSV6 Pfam PF01974 Entrez Gene 79042 Kegg hsa:79042 ENZYME 3.1.27.9

References

UniProt :accession Q9BSV6