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Semaglutide Oral
see semaglutide
Indications:
- treatment of diabetes mellitus type-2
- add on to metformin
Dosage:
- oral semaglutide (Rybelsus) 7 mg & 14 mg (FDA-approved Sept 2019) [1,2]
- doses as high as 50 mg safe & effective [3]
Interactions
drug adverse effects of hypoglycemic agents
General
semaglutide (Ozempic, Rybelsus, Wegovy)
oral agent
References
- Husain M, Birkenfeld AL, Donsmark M et al.
Oral semaglutide and cardiovascular outcomes in patients with
type 2 diabetes.
N Engl J Med 2019 Jun 11
PMID: 31185157
https://www.nejm.org/doi/10.1056/NEJMoa1901118
- Tucker ME
FDA OKs 'Game-Changer' Oral GLP-1 Agonist for Type 2 Diabetes.
Medscape - Sep 20, 2019.
https://www.medscape.com/viewarticle/918772
- Aroda VR et al.
Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with
14 mg in adults with type 2 diabetes (PIONEER PLUS): A multicentre, randomised,
phase 3b trial.
PMID: 37385279
Lancet 2023 Jun 25; [e-pub].
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01127-3/fulltext
- Knop FK et al.
Oral semaglutide 50 mg taken once per day in adults with overweight or obesity
(OASIS 1): A randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet 2023 Jun 25; [e-pub]
PMID: 37385278
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01185-6/fulltext