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selenium deficiency; Keshan disease
Etiology: selenium deficiency
Epidemiology:
1) Keshan disease observed spreading in 1935 in rural areas of Heilongjiang province in northern China (1st reported in Keshan county)
2) Keshan disease affects mostly children & women of child-bearing age
3) endemic in rural northern China
4) widespread selenium deficiency found in all regions of the brains examined in patients with Huntington's disease [2]
Pathology:
- myocardial injury
Clinical manifestations:
- Keshan disease frequently occurs without warning
- Huntington's disease? [2]
Complications:
- may be fatal
Management:
- sodium selenite (Na2SeO3) or selenomethionine
Related
selenium [Se]
selenoprotein
General
mineral deficiency
References
- Tungsheng L
Selenium in: Chemical & Engineering News, Sept 8, 2003, page 94
- George J
Widespread Selenium Deficiency Seen in Huntington's Disease Brains
- Researchers caution about self-medicating
MedPage Today October 24, 2023
https://www.medpagetoday.com/neurology/generalneurology/106970
- Scholefield M, Patassini S, Xu J, Cooper GJS.
Widespread selenium deficiency in the brain of cases with Huntington's disease
presents a new potential therapeutic target.
eBioMedicine. 2023 Oct 6:97:104824
PMID: 37806287
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00390-0/fulltext