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selective estrogen receptor modulator (SERM)
A term used for modulators of the estrogen receptor
1) tamoxifen (estrogen receptor antagonist)
2) raloxifene (mixed estrogen receptor antagonist/agonist)
3) toremifene
Indications:
- preventive effects against breast cancer up to 5 years after therapy ends [1]
- effect mostly due to reductions in estrogen receptor- positive breast cancer
- endometrial cancer [2]
- ovarian cancer
- osteoporosis
- atrophic vaginitis [2]
Adverse effects:
- thromboembolism
Interactions
drug adverse effects of selective estrogen receptor modulator(s)
Related
estrogen antagonist
estrogen receptor
Specific
bazedoxifene
ospemifene (Osphena)
raloxifene (Evista)
tamoxifen (Novaldex, Soltamox)
toremifene (Fareston)
General
endocrine agent
References
- Cuzick J et al
Selective oestrogen receptor modulators in prevention of
breast cancer: an updated meta-analysis of individual
participant data.
The Lancet, Early Online Publication, 30 April 2013
PMID: 23639488
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60140-3/abstract
- Deprecated Reference