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selectin
A family of Ca+2-dependent (C-type) mammalian lectins found on cells of the vascular system. Selectins are important for adhesion of leukocytes to endothelial cells during flow because of rapid on/off rates of binding. Integrins are more important for leukocyte adhesion during stasis because of higher binding affinities.
Specific
CD62E, E-selectin; endothelial leukocyte adhesion molecule 1; ELAM-1; leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62 antigen-like family member E (SELE, ELAM1)
CD62L, L-selectin; lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; Mel-14; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62 antigen-like family member L (SELL, LNHR, LYAM1)
CD62P, P-selectin; granule membrane protein 140; GMP-140; PADGEM; leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P (SELP, GMRP, GRMP)
General
adhesion receptor
glycoprotein
immunoglobulin superfamily protein
lectin
Properties
COMPARTMENT: plasma membrane
MOTIF: lectin module
EGF domain
consensus repeat (SEVERAL)
transmembrane domain
References
- Springer TA, Lasky LA.
Cell adhesion. Sticky sugars for selectins.
Nature. 1991 Jan 17;349(6306):196-7. No abstract available.
PMID: 1987472
- Chien, S, Molecular & mechanical bases of
leukocyte-endothelial adhesion. Seminar,
University of Mississippi Medical Center,
Jan. 12, 1993