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secretory diarrhea
Etiology:
- pharmaceuticals
- NSAIDs, colchicine
- endocrine neoplasms
- carcinoid, gastrinoma, VIPoma
- small intestinal bacterial overgrowth
- bile acid malaborption
- short bowel syndrome
- villous adenoma
Clinical manifestations:
- watery nocturnal bowel movements
- large volume
- unchanged by fasting
- dehyration
Laboratory:
- stool osmolality < 340 mosm/kg
- serum elctrolyte disturbances
- serum sodium: hyponatremia, serum potassium: hypokalemia
Special laboratory:
- colonoscopy to evaluate for villous adenoma
Specific
congenital chloride diarrhea
hereditary diarrhea type 2
hereditary diarrhea type 3
hereditary diarrhea type 4
General
diarrhea
References
- Medical Knowledge Self Assessment Program (MKSAP) 14, 18
American College of Physicians, Philadelphia 2006, 2018.
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022