protein transport protein Sec31A (SEC31-related protein A, SEC31-like 1, ABP125, ABP130, Web1-like protein, SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334)

Function: - component of COPII coat Structure: - belongs to the WD repeat SEC31 family - contains 7 WD repeats Compartment: - cytoplasm, cytoplasmic vesicle - COPII-coated vesicle membrane - peripheral membrane, cytoplasmic side - endoplasmic reticulum membrane - association with membranes is GTP-dependent Alternative splicing: named isoforms=8 Expression: - abundantly & ubiquitously expressed Pathology: - chromosomal translocation t(2;4)(p23;q21) involving SEC31A with ALK is associated with inflammatory myofibroblastic tumors

General

phosphoprotein WD repeat protein family

Properties

SIZE: MW = 133 kD entity length = 1220 aa COMPARTMENT: cytoplasm endoplasmic reticulum MOTIF: WD repeat {68-111} WD repeat {120-160} interaction with SEC13 {161-471} MOTIF: WD repeat {166-206} WD repeat {209-254} WD repeat {258-298} WD repeat {301-342} Ser phosphorylation site {S527} Ser phosphorylation site {S532} WD repeat {674-715} Ser phosphorylation site {S799} interaction with PDCD6 {800-1113} MOTIF: proline-rich region SITE: 800-1091 MOTIF: proline residue (SEVERAL) Thr phosphorylation site {T1161}

Database Correlations

UniProt O94979 Pfam PF00400

References

UniProt :accession O94979