SEA domain

Function: - extracellular domain of unknown function - found in 1 or 2 copies in mosaic extracellular or transmembrane proteins - associated with regions of O-glycosylation - associated regions of O-glycosylation - glycosylation may stabilize SEA domains & protect them from proteolysis Length: about 120 amino acid residues Domain named after the 1st 3 proteins in which it was identified: - Sperm protein (sea urchin) - Enterokinase - Agrin Other proteins containing SEA domain include: - perlecan - interphotoreceptor matrix proteoglycan 1 - epithelial mucins - cell surface antigen 114/A10

General

exoplasmic motif domain

References

prosite :accession PS50024