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serum deprivation-response protein (phosphatidylserine-binding protein, PS-p68, SDPR)
Function:
1) may play a role in targeting PRKCA to caveolae
2) binds to PRKCA in the presence of phosphatidylserine
3) up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition
4) down-regulated during synchronous cell cycle re-entry
5) phosphorylated on Ser
6) binds phosphatidylserine (Ca+2-dependent)
7) PS-binding is inhibited by phosphatidic acid & phosphatidyl- inositol
8) does not bind phosphatidylcholine
Compartment: cytoplasm, colocalizes with CAV1 to caveolae
Expression:
- expresed in heart, lung > brain, kidney, liver, pancreas, placenta, skeletal muscle
General
phosphoprotein
Properties
SIZE: MW = 47 kD
entity length = 424 aa
COMPARTMENT: cytoplasm
MOTIF: coiled coil {60-81}
coiled coil {124-153}
coiled coil {209-267}
Database Correlations
OMIM 606728
UniProt O95810
References
UniProt :accession O95810