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succinate dehydrogenase cytochrome b small subunit (cybS, succinate dehydrogenase complex subunit D, SDHD)
Function:
- component of mitochondrial electron transport complex 2 (succinate dehydrogenase) which transfers electrons from succinate to ubiquinone (coenzyme Q)
- carbohydrate metabolism; tricarboxylic acid cycle
Structure: belongs to the CybS family
Compartment: mitochondrial inner membrane
Pathology:
- defects in SDHD are a cause of hereditary paraganglioma type 1
- defects in SDHD are a cause of pheochromocytoma
- defects in SDHD are involved in intestinal carcinoid tumor
Related
SDHD (succinate dehydrogenase complex subunit D) gene
General
cytochrome
mitochondrial membrane protein
Properties
SIZE: entity length = 159 aa
MW = 17 kD
COMPARTMENT: mitochondria
MOTIF: transmembrane domain {71-91}
Iron [Fe]-binding site
SITE: 102-102
Iron [Fe]-binding site
SITE: 104-104
transmembrane domain {126-142}
Database Correlations
OMIM correlations
MORBIDMAP 602690
UniProt O14521
Pfam PF05328
Kegg hsa:6392
References
- UniProt :accession O14521
- Atlas of genetics & cytogenetics in oncology & Haematology
http://atlasgeneticsoncology.org/genes/SDHDID390.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SDHD
- Wikipedia; Note: SDHD entry
http://en.wikipedia.org/wiki/SDHD
Component-of
succinate dehydrogenase (mitochondrial complex 2)