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scyllo-inositol; cocositol; quercinitol; 1,3,5/2,4,6-hexahydroxycyclohexane (AZD-103)

one of the 8 naturally occuring stereoisomers of inositol Epidemiology: - found most abundantly in the coconut palm Dosage: - 250 PO BID Pharmacokinetics: - penetrates blood brain barrier - administration leads to increases in CSF concentration Adverse effects: - dosages of 1000 mg BID & 2000 mg BID may increase risk of infection & death [4] Mechanism of action: - can block the development of beta-amyloid senile plaques in brains of transgenic mice Clinical trials: - decreases CSF Abeta 1-42 [4] - clinical efficacy outcomes were not significant in phase 2 trial [4]

General

inositol

Database Correlations

PUBCHEM cid=892

References

  1. PubChem: 892
  2. Wikipedia: scyllo-Inositol http://en.wikipedia.org/wiki/Scyllo-Inositol
  3. McLaurin J et al Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med. 2006 Jul;12(7):801-8. Epub 2006 Jun 11. PMID: 16767098
  4. Salloway S et al A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. 2011 Sep 27;77(13):1253-62. Epub 2011 Sep 14. PMID: 21917766 http://www.neurology.org/content/77/13/1253.abstract
  5. Fenili D et al Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology. J Mol Med (Berl). 2007 Jun;85(6):603-11. Epub 2007 Feb 6. PMID: 17279347