protein LAP4 (protein scribble homolog, hScrib, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL)

Function: 1) role in polarization of epithelia ( putative) 2) interacts through its PDZ domains with VANGL2 3) interacts with UBE3A, HPV E6 & LPP 4) ubiquitinated Structure: 1) belongs to the LAP (LRR & PDZ) protein family 2) contains 18 LRR repeats (leucine-rich repeats) - contains 4 PDZ domains (DHR domains) Compartment: - cytoplasm, peripheral membrane - localized to cell junctions Alternative splicing: named isoforms=4 Pathology: - targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins & degradated

Properties

SIZE: MW = 175 kD entity length = 1630 aa COMPARTMENT: cytoplasm MOTIF: leucine-rich repeat SITE: 11-34 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 35-57 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 58-81 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 83-105 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 107-126 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 127-149 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 150-172 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 173-195 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 196-219 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 221-241 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 242-265 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 267-287 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 288-310 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 311-334 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 336-357 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 359-380 MOTIF: leucine residue (SEVERAL) coiled coil {458-474} coiled coil {656-701} MOTIF: glutamate-rich region {660-695} MOTIF: glutamate residue (SEVERAL) PDZ domain NAME: PDZ domain SITE: 728-815 PDZ domain NAME: PDZ domain SITE: 862-950 PDZ domain NAME: PDZ domain SITE: 1004-1093 PDZ domain NAME: PDZ domain SITE: 1100-1194 MOTIF: Ser phosphorylation site {S1140} leucine-rich repeat SITE: 1152-1175 MOTIF: leucine residue (SEVERAL) Ser phosphorylation site {S1220} leucine-rich repeat SITE: 1258-1282 MOTIF: leucine residue (SEVERAL) proline-rich region SITE: 1296-1349 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1309} Ser phosphorylation site {S1348} coiled coil {1379-1419} Ser phosphorylation site {S1448} Ser phosphorylation site {S1475} Ser phosphorylation site {S1486} Ser phosphorylation site {S1566}

Database Correlations

OMIM 607733 UniProt Q14160 PFAM correlations

References

UniProt :accession Q14160