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scrapie
Prion disease in sheep & goats.
Pathology:
1) presence of differentiated B-lymphocytes is important for invasion of the nervous system after intraperitoneal innoculation of mice
2) after innoculation into limbs, scrapie agent travels along peripheral nerves to central nervous system
Related
CD230 or major prion protein (PrP)
transmissible spongiform encephalopathy (prion disease)
General
animal spongiform encephalopathy
References
Johnson & Gibbs NEJM 339:1994, 1998