PH domain leucine-rich repeat protein phosphatase; suprachiasmatic nucleus circadian oscillatory protein; hSCOP, (PHLPP, PHLPP1, KIAA0606, PLEKHE1, SCOP)

Function: 1) mediates dephosphorylation of Ser-473 of AKT1 2) triggers apoptosis & suppression of tumor growth 3) negative regulator of K-Ras signaling in the membrane rafts. 4) insensitive to okadaic acid Compartment: cytoplasm, membrane Expression: ubiquitous Pathology: - down-regulated in colon cancer & glioblastoma cell lines

General

pleckstrin homology domain containing family serine/threonine phosphatase

Properties

SIZE: MW = 185 kD entity length = 1717 aa COMPARTMENT: cytoplasm MOTIF: alanine-rich region {4-137} (3) MOTIF: alanine residue (SEVERAL) serine-rich region {138-144} MOTIF: serine residue (SEVERAL) alanine-rich region {145-257} (2) MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 463-469 MOTIF: proline residue (SEVERAL) PH domain {536-636} leucine-rich repeat (18) SITE: 636-1129 MOTIF: leucine residue (SEVERAL) PP2C-like {1165-1420} MOTIF: manganese [Mn]-binding site (5) SITE: 1210-1413 leucine-rich repeat SITE: 1515-1538 MOTIF: leucine residue (SEVERAL) glutamine-rich region {1682-1689} MOTIF: glutamine residue (SEVERAL) STATE: active state

Database Correlations

UniProt O60346 PFAM correlations ENZYME 3.1.3.16

References

UniProt :accession O60346